Direct Effects of Colchicine on Myocardial Function

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Direct effects of colchicine on myocardial function: studies in hypertrophied and failing spontaneously hypertensive rats.

-The aging spontaneously hypertensive rat (SHR) is a model in which the transition from chronic stable left ventricular hypertrophy to overt heart failure can be observed. Although the mechanisms for impaired function in hypertrophied and failing cardiac muscle from the SHR have been studied, none accounts fully for the myocardial contractile abnormalities. The cardiac cytoskeleton has been imp...

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ژورنال

عنوان ژورنال: Hypertension

سال: 1999

ISSN: 0194-911X,1524-4563

DOI: 10.1161/01.hyp.33.1.60